Cystic Fibrosis Mini Project
Question Description
For this project, it is not enough to simply answer the questions below. The questions below are a guide for what you need to discuss (i.e. show that you understand the concept) for this project.
Questions to be used as a guide in the project1. What is cystic fibrosis?
2. Describe the structure and function of the NORMAL CFTR protein. In what cells are they found?
3. Name 3 organ systems that are affected by cystic fibrosis. Why are they affected this way?
4. Here are 3 mutated variants of the CFTR protein. Choose ONE and talk about how this mutation causes a change in the activity of the CFTR protein
.a. G542X
b. G551D
c. D1152H
5. Name 3 treatments for cystic fibrosis. How do they work?
Resources you can use for this project:
https://www.cff.org/Care/Clinician-Resources/Network-News/August-2017/Know-Your-CFTR-Mutations.pdf
https://www.vrtx.com/research-development/pipeline/cystic-fibrosis/
