Describe the biosafety level classification system in the U.S. and the biohazard risk classification used by the WHO.

Describe the biosafety level classification system in the U.S. and the biohazard risk classification used by the WHO. What additional safety concerns are there for BL3-LS? What documentation and additional safety precautions would a company need to take to manufacture at this level? What building modifications might be required and how might the production process be modified?